Best-rated hotels in Big Pine Key for your unforgettable stay

Detailed descriptions, travelers’ reviews, and handpicked hotel collections will help you book your perfect accommodation.

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Choose from exclusive hotel collection

We offer thousands of Big Pine Key hotels and accommodations from world's renowned hotel chains to unique gems of the region you won’t find anywhere else.

Enjoy seamless booking experience

Once you choose your best place to stay, take a minute to complete a quick reservation form and get an instant confirmation letter to your email address.

Benefit from flexible travel options

We provide the most flexible cancellation options, so you get your deposit back in case of a change of plans or other unforeseen circumstances.

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Hotels by class
3 stars 2
2 stars 1
Unrated 24
Accommodation type
Holiday homes 17
Apartments 4
Bed & Breakfasts 2
Campsite 1
Motel 1
Hotel 1
Lodge 1
Thematic Hotels
Vacation Rentals 21
Extended Stay 21
Pet-friendly hotels 18
Cheap and budget hotels 8
Luxury accommodations 7
Hotels with indoor pool 7
Beach hotels 6
Beachfront hotels 5
Jacuzzi 4
Private Villas 3
Family Friendly hotels 3
Spa hotels 1
Central hotels 1
Resorts 1
All Big Pine Key hotels

Hotels by location

Nearby
Big Pine Key Shopping Center 17
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Florida Keys >
Big Pine Key

Welcome to Big Pine Key

Discover the natural beauty of Big Pine Key, nestled in the heart of the Florida Keys. Immerse yourself in clear turquoise waters as you snorkel amongst vibrant coral reefs, or take a leisurely stroll along our pristine white sand beaches. Don't miss out on the chance to encounter our beloved Key deer who gracefully roam the island. Plan your visit to Big Pine Key today and experience the ultimate tropical getaway.

What our users say about Big Pine Key hotels

Oceans Edge Key West
9.8

Exceptional

us Michael 14 February 2023
This brand-new place is pretty clean with very friendly staff.
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Opal Key Resort & Marina
9.8

Exceptional

us John 16 December 2022
The rooms were spacious and practical with a stunning view, and it was nice to have a safe box, flat screen cable TV, and a refrigerator.
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Hilton Garden Inn Key West / The Keys Collection
9.8

Exceptional

us Jerry 21 May 2022
Nice room with a balcony to enjoy the view. The staff was really helpful, even letting us check in early 🌞.
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Blue Flamingo Resort Key West
9.8

Exceptional

us Eric 18 December 2022
Great location with on-site parking making it super convenient. The pool area is awesome too 🏊. The staff here are helpful and efficient.
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Faro Blanco Resort Marathon Florida Keys, Curio By Hilton
9.8

Exceptional

us Ed 25 December 2022
Comfortable and clean rooms with a trendy vibe, and the staff were really helpful. the beds were cozy too. It's a great spot for a business trip with a lot of character! 👌
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Parrot Key Hotel & Villas
9.8

Exceptional

us Jessica 16 November 2022
This place has clean and modern rooms located in a peaceful beachfront setting. the breakfast options are fantastic - think grill goodies and delicious bagels to kick off your day! 🌴
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Havana Cabana At Key West (Adults Only)
9.8

Exceptional

us Wayne 27 February 2023
The staff was pleasant and attentive. The room with the king bed was nice. The outdoor restaurant and poolside bar were convenient.
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The Gates Hotel Key West
9.8

Exceptional

us George 28 July 2022
We loved the nicely finished rooms, and having a shower, hair dryers, and towels was a great addition.
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Islander Resort
9.8

Exceptional

us Charles 17 May 2021
Can't wait to say thank you, will certainly stay here again. Generous-sized suite and soft bed. Cozy location just a short stroll away from florida keys memorial.
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Cheeca Lodge & Spa
9.8

Exceptional

us Byron 14 July 2020
we thoroughly enjoyed the amenities, such as a flat-screen tv with cable channels, a dining area and ironing facilities. would stay here again when in islamorada, its dope!
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Save time on your trip arrangements by booking one of our hand-picked hotels

Exclusive 3-star hotels
Quality 2-star hotels
Enjoy truly authentic experiences without compromising comfort and convenience.
Deer Run On The Atlantic Bed & Breakfast

1997 Long Beach Road, Big Pine Key, United States

Excellent
5 reviews

517 US$

min. price/night

Barnacle Bed And Breakfast

1557 Long Beach Drive, Big Pine Key, United States

413 US$

min. price/night

Discover the hidden gems of Big Pine Key by booking one of its budget-friendly hotels.
Sunshine Key Rv Resort & Marina

38801 Overseas Highway, Big Pine Key, United States

Excellent
72 reviews

255 US$

min. price/night

Travelers’ choice

Check out the most booked accommodations to find reliable places that our users have tried and tested.
Old Wooden Bridge Resort & Marina

1791 Bogie Drive, Big Pine Key, United States

Excellent
291 reviews

246 US$

min. price/night

Big Pine Key Motel

30725 Overseas Highway, Big Pine Key, United States

Good
14 reviews

169 US$

min. price/night

Treehouse Private Village At Barnacle Resort

Long Beach Drive 1557, Big Pine Key, United States

Good
3 reviews

476 US$

min. price/night

Star Room At Barnacle Resort

Long Beach Drive 1557

Excellent
3 reviews

292 US$

min. price/night

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